Fig. 5. Diagrammatic representation reflecting the role of RA signalling in pancreas specification during early Xenopus embryogenesis During gastrulation, the expression of Fzd4 and Hnf1β is directly induced by RA. The overlapping activity of Fzd4 and Hnf1b establishes a pre-pancreatic domain within the dorsal endoderm. Fzd4/Fzd4s is a regulator of Wnt-signalling within the dorsal endoderm, which modulates Wnt-signalling to a level that allows the specification of pancreatic progenitors characterized by the co-expression of Ptf1a and Pdx1. Pancreatic progenitors subsequently proliferate and differentiate into endocrine and exocrine tissue.
Image published in: Gere-Becker MB et al. (2018)
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