Figure 7. Id genes orchestrate cardiogenic mesoderm differentiation in vertebrates. Id genes control the activation of the cardiogenic mesoderm differentiation program in mesendoderm progenitors by inhibiting the activity of repressors (Tcf3 and Foxa2) while promoting the expression of activators of cardiogenic mesoderm differentiation (Evx1, Grrp1, and Mesp1). The Id-controlled network induces cardiogenic mesoderm (Mesp1 and Kdr) differentiation from pluripotent cells. Id1-induced CMPs generated from pluripotent stem cells are cryopreservable and spontaneously form contracting cardiomyocytes (∼70%) as well as vascular endothelial cells, smooth muscle, and fibroblasts.
Image published in: Cunningham TJ et al. (2017)
Copyright © 2017. Image reproduced on with permission of the Publisher, Cold Spring Harbor Laboratory Press. This is an Open Access article.
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