19th International Xenopus Conference

The 19th International Xenopus Conference August 20-24, 2023, Cambridge, Maryland, USA.

Register soon, as attendance is limited to 300 participants.

Trainee Travel award application deadline May 25th

General Registration and Abstract Submission deadline July 1, 2023.

Virtual Attendance Registration deadline June 25, 2023.

Merchandise now available for order!

RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis

Wong et al. document the first human phenotype resulting from the germline loss-of-function of the proto-oncogene RAF1 (a.k.a. CRAF). In cultured cells and in vivo using Xenopus assays RAF1 p.Thr543Met mutation acted as a loss-of-function allele abolishing downstream ERK pathway signaling.

Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease

Mishra-Gorur et al. publish in PNAS inherited mutations of TRAF7 cause congenital heart disease while somatic mutations cause brain tumors. Shared genetics of the disparate pathologies can be traced to the common developmental origin of the tissues from the neural crest.

CRISPR/Cas9-based simple transgenesis in Xenopus laevis

Shibata et al. established a simple transgenesis method for X. laevis based on CRISPR/Cas9 technology - NEXTrans (New and Easy Xenopus Transgenesis) using common single guide RNA (sgRNA) and a preset donor vector for more efficient target integration into a putative harbor site.

Prof Christine Holt awarded the Brain Prize

Dr. Christine Holt with Dr. Erin Shuman and Dr. Michael Greenberg awarded the Lundbeck Foundation 2023 Brain Prize for their major contributions to modern neurobiology.

Single-cell profiling of Xenopus mucociliary epithelium

Lee et al. profile the developing Xenopus mucociliary epithelium from pluripotent to mature stages by single-cell transcriptomics. This work sheds light on normal mucociliary development and provides avenues to study dysregulated epithelium in diseases like asthma or COPD. Science Advances.

Xenbase joins the Alliance of Genome Resources

A big leap forward for Alliance of Genome Resources (AGR) with the inclusion of Xenopus data from Xenbase

Check out the AGR...

Normal Table of Xenopus development: a new graphical resource

Zahn et al. published in Develoment a new normal table resource of images chronicling the development of Xenopus frogs.

View the Zahn drawings and landmarks table on Xenbase.

View the accompanying poster.

19th International Xenopus Conference

The 19th International Xenopus Conference August 20-24, 2023, Cambridge, Maryland, USA.

Register soon, as attendance is limited to 300 participants.

Trainee Travel award application deadline May 25th

General Registration and Abstract Submission deadline July 1, 2023.

Virtual Attendance Registration deadline June 25, 2023.

Merchandise now available for order!