• SDB 80th Annual Meeting

    Society for Developmental Biology
    80th Annual Meeting
    Virtual, July 12-16, 2021

    Registration Deadline is June 14, 2021, 11:59 PM ET

     

    Eddy De Robertis to receive SDB Lifetime Achievement Award

     

    Read More...
  • The Scf/Kit pathway implements self-organised epithelial patterning

    Social distancing is no mystery to Xenopus cells! Chuyen et al. report how thousands of multiciliated cells distribute into a regular pattern in the developing epidermis, through homotypic repulsion and homing at intercalation sites. Published in Developmental Cell.

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  • Biallelic variants in COPB1 cause a novel, severe intellectual disability syndrome with cataracts and variable microcephaly

    CRISPR/Cas9-mediated mutation of Coat protein complex 1 (COPI) subunit COPB1 in X. tropicalis recapitulates features of the human "coatopathy" syndrome including microcephaly and cataracts. Published in Genome Medicine.

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  • Genesis Special Issue: Aquatic Models of Developmental Disorders

    Published February 2021

     

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  • 18th International Xenopus Conference

    The 18th International Xenopus Conference will be going ahead as planned, either as a virtual or a blended meeting. August 15-19, 2021.

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  • Chromatin accessibility and transcription factor activity (during gastrulation)

    Single‐cell chromatin‐accessibility and transcriptomic analyses identify the contribution and cooperation of key transcription factors in zygotic gene expression. Transcriptional heterogeneity at the gastrula stage of vertebrate embryogenesis is involved in mesoderm induction, dorsal‐ventral patterning, and establishment of the dorsal axis. Bright et al. published in EMBO J.

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  • Lrp2-mediated endocytosis is essential for neural tube closure

    Kowalczyk et al. identify a conserved role for Lrp2 in anterior neural tube closure and forebrain development. Loss of Lrp2 affects both apical constriction as well as planar cell polarity. Published in Development.

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  • Eddy De Robertis conferred SDB lifetime achievement award

    Dr. Edward (Eddy) M. De Robertis, Distinguished Professor, Biological Chemistry, Norman F. Sprague Chair of Molecular Oncology Investigator, University of California Los Angeles and Howard Hughes Medical Institute investigator, has been awarded the 2021 Society of Developmental Biology Lifetime Achievement Award.

     

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  • Notch signaling induces cell death or cell fate change of multiciliated cells

    Tasca et al. describe how multiciliated cells are removed from airway-like mucociliary epithelia during developmental tissue remodeling. In addition to cell death, these highly specialized cells can also change their identity toward another cell type, which was considered impossible, challenging the concept of terminal differentiation. Published in Developmental Cell.

     

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  • Nasco will stop selling Xenopus

    The number of suppliers of Xenopus animals is changing.

    Click below to read about optons to purchase live animals.

     

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  • Phenotypes on Xenbase

    The latest release of Xenbase includes the ability to search for Phenotypes.

     

    Click here to go to the Phenotype search page.

     

    Click here to find details on executing a Phenotype search.

     

    Click here to find details on the Xenopus Phenotype Ontology (XPO).

     

     

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  • Xenbase Winter Newsletter 2020

    Please follow this link to the Xenbase Winter Newsletter 2020.

     

    Read the PDF for more details.

     

    The newsletter archive can be found here.

     

     

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  • Xenopus tropicalis v10 genome

    - available to BLAST

    - view on JBrowse

     

    99.86% of the genome mapped to chromosomes
    ~4500 new and refined models, 18% not present in trop v9.1

     

    Click here to view the release document.

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  • 2020 Xenopus White Paper

    The 2020 Xenopus Community White Paper is now available!

    PIs: Please reference the White Paper in your NIH grant proposals and contact your program officers.

    Download the 2020 Xenopus White Paper:

    Word Document

    PDF

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  • SDB 80th Annual Meeting

    Society for Developmental Biology
    80th Annual Meeting
    Virtual, July 12-16, 2021

    Registration Deadline is June 14, 2021, 11:59 PM ET

     

    Eddy De Robertis to receive SDB Lifetime Achievement Award

     

    Read More...

Xenopus is an essential vertebrate model system for biomedical research

  • Share 83% human disease genes
  • Ease of genomic manipulation
  • Large eggs and embryos with rapid external development
  • Ease of housing
  • Produce hardy eggs year-round
  • Learn more about Xenopus


The Xenopus model organism knowledgebase
Xenbase is a web-accessible resource that integrates all the diverse biological, genomic, genotype and phenotype data available from Xenopus research. Learn more about Xenbase.