• Cytoplasmic organization promotes protein diffusion in Xenopus extracts

     

    Huang et al. use Xenopus laevis egg extracts as a model system to study diffusion dynamics in organized versus disorganized cytoplasm. Nature Communications.

     

    Read More...
  • Membrane potential affects pluripotency

     

    Sempou et al. demonstrate the electrical properties of embryonic stem cells can play a critical role in the transition from pluripotency to a differentiated state. Nature Communications.

     

    Read More...
  • Multiciliated cells probe mechanical environment during epithelial integration

     

    Ventura and Amiri et al. in Nature Communications reveal how migrating cells in the Xenopus embryo join a tissue by using finger-like extensions (filopodia) to read mechanical information from neighboring cells. Adding new cells into tissue is a key process in sculpting organs during normal development, but it is subverted during the metastatic spread of cancer cells.

     

    Read More...
  • Cell clusters softening triggers collective cell migration in vivo

     

    Marchant et al. demonstrate in Nature Materials cells within clusters from embryonic tissue dynamically decrease their stiffness in response to temporal stiffening of the native substrate initiating collective cell migration.

    They further show decreasing microtubule acetylation and consequent cluster stiffness is sufficient to trigger collective cell migration in soft non-permissive substrates.

     

    Read More...
  • Xenbase joins the Alliance of Genome Resources

     

    A big leap forward for Alliance of Genome Resources (AGR) with the inclusion of Xenopus data from Xenbase

     

    Check out the AGR...

     

    Read More...
  • 19th International Xenopus Conference

     

    Save the date!

    Cambridge, Maryland USA

    August 20-24, 2023

     

    19thXenopusconference.org

     

    Details on registration, travel awards for graduate students and postdocs, and meeting program coming soon.

     

    #FrogFest23

     

    Read More...
  • Normal Table of Xenopus development: a new graphical resource

     

    Zahn et al. published in Develoment a new normal table resource of images chronicling the development of Xenopus frogs.

    View the Zahn drawings and landmarks table on Xenbase.

    View the accompanying poster.

     

    Read More...
  • Cell landscape of larval and adult Xenopus laevis at single-cell resolution

     

    Liao et al. published in Nature Communications their construction of the first Xenopus cell landscape to date, including larval and adult organs. They identify common cell lineage-specific transcription factors in vertebrates, including fish, amphibians and mammals. They provide a large-scale resource for research on Xenopus metamorphosis and adult organs.

     

    Read More...
  • Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex

     

    Zhu et al. published in Science the single-particle cryo–electron microscopy reconstruction of the cytoplasmic ring subunit from the Xenopus laevis nuclear pore complex at 3.7- to 4.7-angstrom resolution.

     

     

    Read More...
  • Vertebrate Cranial Placodes

     

    Dr. Gerhard Schlosser published a two-volume book set through CRC Press detailing the development and evolution of vertebrate cranial placodes.

     

    Read More...
  • Phenotypes on Xenbase

    The latest release of Xenbase includes the ability to search for Phenotypes.

     

    Click here to go to the Phenotype search page.

     

    Click here to find details on executing a Phenotype search.

     

    Click here to find details on the Xenopus Phenotype Ontology (XPO).

     

     

    Read More...
  • Xenopus laevis v10.1 and Xenopus tropicalis v10 genomes

     

    - both genomes fully integrated into Xenbase

    - BLAST mRNA, protein, and CDS

    - viewable on JBrowse

    - morpholino tracks aligned

    - relevant files available on Xenbase FTP and downloads page

     

    Read More...
  • Cytoplasmic organization promotes protein diffusion in Xenopus extracts

     

    Huang et al. use Xenopus laevis egg extracts as a model system to study diffusion dynamics in organized versus disorganized cytoplasm. Nature Communications.

     

    Read More...

Xenopus is an essential vertebrate model system for biomedical research

  • Share 83% human disease genes
  • Ease of genomic manipulation
  • Large eggs and embryos with rapid external development
  • Ease of housing
  • Produce hardy eggs year-round
  • Learn more about Xenopus


The Xenopus model organism knowledgebase
Xenbase is a web-accessible resource that integrates all the diverse biological, genomic, genotype and phenotype data available from Xenopus research. Learn more about Xenbase.