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XB-ART-59231
Nat Commun January 1, 2022; 13 (1): 4306.
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Cell landscape of larval and adult Xenopus laevis at single-cell resolution.

Liao Y , Ma L , Guo Q , E W , Fang X , Yang L , Ruan F , Wang J , Zhang P , Sun Z , Chen H , Lin Z , Wang X , Wang X , Sun H , Fang X , Zhou Y , Chen M , Shen W , Guo G , Han X .


Abstract
The rapid development of high-throughput single-cell RNA sequencing technology offers a good opportunity to dissect cell heterogeneity of animals. A large number of organism-wide single-cell atlases have been constructed for vertebrates such as Homo sapiens, Macaca fascicularis, Mus musculus and Danio rerio. However, an intermediate taxon that links mammals to vertebrates of more ancient origin is still lacking. Here, we construct the first Xenopus cell landscape to date, including larval and adult organs. Common cell lineage-specific transcription factors have been identified in vertebrates, including fish, amphibians and mammals. The comparison of larval and adult erythrocytes identifies stage-specific hemoglobin subtypes, as well as a common type of cluster containing both larval and adult hemoglobin, mainly at NF59. In addition, cell lineages originating from all three layers exhibits both antigen processing and presentation during metamorphosis, indicating a common regulatory mechanism during metamorphosis. Overall, our study provides a large-scale resource for research on Xenopus metamorphosis and adult organs.

PubMed ID: 35879314
Article link: Nat Commun
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: hba1 hbd


Article Images: [+] show captions
References [+] :
Aztekin, Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs. 2021, Pubmed, Xenbase