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XB-ART-57556
Genes (Basel) January 1, 2020; 11 (11):

Hes5.9 Coordinate FGF and Notch Signaling to Modulate Gastrulation via Regulating Cell Fate Specification and Cell Migration in Xenopus tropicalis.

Huang X , Zhang L , Yang S , Zhang Y , Wu M , Chen P .


Abstract
Gastrulation drives the establishment of three germ layers and embryonic axes during frog embryonic development. Mesodermal cell fate specification and morphogenetic movements are vital factors coordinating gastrulation, which are regulated by numerous signaling pathways, such as the Wnt (Wingless/Integrated), Notch, and FGF (Fibroblast growth factor) pathways. However, the coordination of the Notch and FGF signaling pathways during gastrulation remains unclear. We identified a novel helix-loop-helix DNA binding domain gene (Hes5.9), which was regulated by the FGF and Notch signaling pathways during gastrulation. Furthermore, gain- and loss-of-function of Hes5.9 led to defective cell migration and disturbed the expression patterns of mesodermal and endodermal marker genes, thus interfering with gastrulation. Collectively, these results suggest that Hes5.9 plays a crucial role in cell fate decisions and cell migration during gastrulation, which is modulated by the FGF and Notch signaling pathways.

PubMed ID: 33218193
PMC ID: PMC7699193
Article link: Genes (Basel)
Grant support: [+]

Species referenced: Xenopus tropicalis
Genes referenced: bix1.1 eomes fgf8 gata4 hes1 hes2 hes4 hes5.2 hes5.7 hes5.9 mixer mrc1 myf5 myod1 nodal1 nodal3.1 notch1 odc1 olig2 olig3 olig4 pax6 rax six3 sms snai2 sox17a sox17b.1 twist1
GO keywords: apoptotic process [+]


Article Images: [+] show captions
References [+] :
Bae, The role of FGF signaling in guiding coordinate movement of cell groups: guidance cue and cell adhesion regulator? 2013, Pubmed