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Wound Repair Regen 2022 Nov 01;306:623-635. doi: 10.1111/wrr.13000.
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To regenerate or not to regenerate: Vertebrate model organisms of regeneration-competency and -incompetency.

Aztekin C , Storer MA .

Why only certain species can regenerate their appendages (e.g. tails and limbs) remains one of the biggest mysteries of nature. Unlike anuran tadpoles and salamanders, humans and other mammals cannot regenerate their limbs, but can only regrow lost digit tips under specific circumstances. Numerous hypotheses have been postulated to explain regeneration-incompetency in mammals. By studying model organisms that show varying regenerative abilities, we now have more opportunities to uncover what contributes to regeneration-incompetency and functionally test which perturbations restore appendage regrowth. Particularly, Xenopus laevis tail and limb, and mouse digit tip model systems exhibit naturally occurring variations in regenerative capacities. Here, we discuss major hypotheses that are suggested to contribute to regeneration-incompetency, and how species with varying regenerative abilities reflect on these hypotheses.

PubMed ID: 35192230
PMC ID: PMC7613846
Article link: Wound Repair Regen
Grant support: [+]

Species referenced: Xenopus laevis

Article Images: [+] show captions
References [+] :
Abrams, A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice. 2021, Pubmed