Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-60288
Int J Mol Sci 2023 Sep 02;2417:. doi: 10.3390/ijms241713593.
Show Gene links Show Anatomy links

β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the Developing Xenopus Thalamus.

Gao J , Lu Y , Luo Y , Duan X , Chen P , Zhang X , Wu X , Qiu M , Shen W .


Abstract
In the vertebrate brain, sensory experience plays a crucial role in shaping thalamocortical connections for visual processing. However, it is still not clear how visual experience influences tissue homeostasis and neurogenesis in the developing thalamus. Here, we reported that the majority of SOX2-positive cells in the thalamus are differentiated neurons that receive visual inputs as early as stage 47 Xenopus. Visual deprivation (VD) for 2 days shifts the neurogenic balance toward proliferation at the expense of differentiation, which is accompanied by a reduction in nuclear-accumulated β-catenin in SOX2-positive neurons. The knockdown of β-catenin decreases the expression of SOX2 and increases the number of progenitor cells. Coimmunoprecipitation studies reveal the evolutionary conservation of strong interactions between β-catenin and SOX2. These findings indicate that β-catenin interacts with SOX2 to maintain homeostatic neurogenesis during thalamus development.

PubMed ID: 37686400
PMC ID: PMC10488257
Article link: Int J Mol Sci
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: ctrl pcna pth sox2
GO keywords: tissue homeostasis [+]
Antibodies: BrdU Ab11 Ctnnb1 Ab23 Ctnnb1 Ab24 Ctnnb1 Ab3 Elavl3 Ab1 Fabp7 Ab3 Gapdh Ab8 Nkx2-2 Ab1 Pcna Ab10 Sox2 Ab1 Sox2 Ab7 Vim Ab5 sox9 Ab6
Morpholinos: ctnnb1 MO1 sox2 MO6


Article Images: [+] show captions
References [+] :
Acosta, Notch destabilises maternal beta-catenin and restricts dorsal-anterior development in Xenopus. 2011, Pubmed, Xenbase