FIG. 6. Electrophysiological properties of recombinant XlP2Y. A, membrane currents (Vh 5 240 mV) evoked by ATP (10â1000 nM, for 180 s) and recorded from a defolliculated oocyte injected with XlP2Y transcript. B, concentration-response curves for fast (M) and slow (L) components of biphasic currents evoked by ATP (10 nM to 100 mM) in defolliculated oocytes. The amplitude of evoked currents were normalized to responses evoked by ATP (1 mM). Each data point is the mean of three observations. C, membrane currents showing a time- and voltage-dependent increase in conductivity (IX) in a defolliculated oocyte injected with XlP2Y transcript. The amplitude of IX was inhibited when suramin (10â100 mM) was present in the superfusate. D, the I/V relationship of IX in the absence (M) and presence (10 mM, ; 30 mM, L; 100 mM, E) of the P2 antagonist, suramin.
Image published in: Bogdanov YD et al. (1997)
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