Fig. 2 Expression of disease-linked ribosome biogenesis factors in X. tropicalis embryos. a Expression of all four genes was detected in the 4-cell and gastrulating embryo. Signal was strongly detected in the neural folds at stage 16 and in the migrating neural crest at stage 22. b At later stages expression of all factors was detected in the facial primordia and developing brain. Note the restricted expression at the midâhindbrain border and forebrain. Expression was also typically detected in ventral mesoderm and hypaxial muscle precursor cells. utp4 mRNA was strongly detected at the site of the future liver. c Red lines labeled a*, b* and c* in diagrams of stage 10 and 28 embryos represent the planes of section shown in a and b
Image published in: Robson A et al. (2016)
© The Author(s). Creative Commons Attribution license
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| rbm28 | X. tropicalis | Throughout NF stage 10 | animal hemisphere | |
| sbds | X. tropicalis | Throughout NF stage 10 | ||
| tcof1 | mfd1, treacle | X. tropicalis | Throughout NF stage 10 | dorsal |
| utp4 | cirh1a, cirhin, tex292 | X. tropicalis | Throughout NF stage 10 | |
| rbm28 | X. tropicalis | Sometime during NF stage 14 to NF stage 15 | cranial neural crest | |
| utp4 | cirh1a, cirhin, tex292 | X. tropicalis | Sometime during NF stage 14 to NF stage 15 | anterior neural fold |
| sbds | X. tropicalis | Throughout NF stage 14 to NF stage 15 | cranial neural crest posterior | |
| tcof1 | mfd1, treacle | X. tropicalis | Throughout NF stage 14 to NF stage 15 | anterior neural fold posterior |
| rbm28 | X. tropicalis | Throughout NF stage 22 | cranial neural crest mandibular crest hyoid crest branchial crest | |
| sbds | X. tropicalis | Throughout NF stage 22 | cranial neural crest mandibular crest hyoid crest branchial crest posterior | |
| tcof1 | mfd1, treacle | X. tropicalis | Throughout NF stage 22 | cranial neural crest branchial crest optic vesicle |
| utp4 | cirh1a, cirhin, tex292 | X. tropicalis | Throughout NF stage 22 | cranial neural crest branchial crest posterior |
| tcof1 | mfd1, treacle | X. tropicalis | Sometime during NF stage 28 to NF stage 29 and 30 | pharyngeal arch mandibular arch hyoid arch branchial arch ventral blood island eye otic vesicle midbrain-hindbrain boundary |
| rbm28 | X. tropicalis | Sometime during NF stage 28 to NF stage 29 and 30 | eye ventral blood island midbrain-hindbrain boundary pharyngeal arch mandibular arch hyoid arch branchial arch hypaxial muscle otic vesicle | |
| sbds | X. tropicalis | Sometime during NF stage 28 to NF stage 29 and 30 | eye pharyngeal arch mandibular arch hyoid arch branchial arch otic vesicle | |
| utp4 | cirh1a, cirhin, tex292 | X. tropicalis | Sometime during NF stage 28 to NF stage 29 and 30 | pharyngeal arch mandibular arch hyoid arch branchial arch midbrain-hindbrain boundary eye posterior |
| rbm28 | X. tropicalis | Throughout NF stage 3 (4-cell) | ||
| sbds | X. tropicalis | Throughout NF stage 3 (4-cell) | ||
| tcof1 | mfd1, treacle | X. tropicalis | Throughout NF stage 3 (4-cell) | blastomere animal blastomere animal animal pole |
| utp4 | cirh1a, cirhin, tex292 | X. tropicalis | Throughout NF stage 3 (4-cell) | |
| tcof1 | mfd1, treacle | X. tropicalis | Sometime during NF stage 35 and 36 to NF stage 40 | brain midbrain-hindbrain boundary otic vesicle pharyngeal arch mandibular arch hyoid arch branchial arch |
| rbm28 | X. tropicalis | Sometime during NF stage 35 and 36 to NF stage 40 | eye midbrain-hindbrain boundary brain otic vesicle pharynx | |
| sbds | X. tropicalis | Sometime during NF stage 35 and 36 to NF stage 40 | head | |
| utp4 | cirh1a, cirhin, tex292 | X. tropicalis | Sometime during NF stage 35 and 36 to NF stage 40 | liver head |
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