Xenbase Image ID: 153532

Fig. 2 Expression of disease-linked ribosome biogenesis factors in X. tropicalis embryos. a Expression of all four genes was detected in the 4-cell and gastrulating embryo. Signal was strongly detected in the neural folds at stage 16 and in the migrating neural crest at stage 22. b At later stages expression of all factors was detected in the facial primordia and developing brain. Note the restricted expression at the mid–hindbrain border and forebrain. Expression was also typically detected in ventral mesoderm and hypaxial muscle precursor cells. utp4 mRNA was strongly detected at the site of the future liver. c Red lines labeled a*, b* and c* in diagrams of stage 10 and 28 embryos represent the planes of section shown in a and b Image published in: Robson A et al. (2016) © The Author(s). Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue rbm28 X. tropicalis Throughout NF stage 10 animal hemisphere sbds X. tropicalis Throughout NF stage 10 tcof1 mfd1, treacle X. tropicalis Throughout NF stage 10 dorsal utp4 cirh1a, cirhin, tex292 X. tropicalis Throughout NF stage 10 rbm28 X. tropicalis Sometime during NF stage 14 to NF stage 15 cranial neural crest utp4 cirh1a, cirhin, tex292 X. tropicalis Sometime during NF stage 14 to NF stage 15 anterior neural fold sbds X. tropicalis Throughout NF stage 14 to NF stage 15 cranial neural crest posterior tcof1 mfd1, treacle X. tropicalis Throughout NF stage 14 to NF stage 15 anterior neural fold posterior rbm28 X. tropicalis Throughout NF stage 22 cranial neural crest mandibular crest hyoid crest branchial crest sbds X. tropicalis Throughout NF stage 22 cranial neural crest mandibular crest hyoid crest branchial crest posterior tcof1 mfd1, treacle X. tropicalis Throughout NF stage 22 cranial neural crest branchial crest optic vesicle utp4 cirh1a, cirhin, tex292 X. tropicalis Throughout NF stage 22 cranial neural crest branchial crest posterior tcof1 mfd1, treacle X. tropicalis Sometime during NF stage 28 to NF stage 29 and 30 pharyngeal arch mandibular arch hyoid arch branchial arch ventral blood island eye otic vesicle midbrain-hindbrain boundary rbm28 X. tropicalis Sometime during NF stage 28 to NF stage 29 and 30 eye ventral blood island midbrain-hindbrain boundary pharyngeal arch mandibular arch hyoid arch branchial arch hypaxial muscle otic vesicle sbds X. tropicalis Sometime during NF stage 28 to NF stage 29 and 30 eye pharyngeal arch mandibular arch hyoid arch branchial arch otic vesicle utp4 cirh1a, cirhin, tex292 X. tropicalis Sometime during NF stage 28 to NF stage 29 and 30 pharyngeal arch mandibular arch hyoid arch branchial arch midbrain-hindbrain boundary eye posterior rbm28 X. tropicalis Throughout NF stage 3 (4-cell) sbds X. tropicalis Throughout NF stage 3 (4-cell) tcof1 mfd1, treacle X. tropicalis Throughout NF stage 3 (4-cell) blastomere animal blastomere animal animal pole utp4 cirh1a, cirhin, tex292 X. tropicalis Throughout NF stage 3 (4-cell) tcof1 mfd1, treacle X. tropicalis Sometime during NF stage 35 and 36 to NF stage 40 brain midbrain-hindbrain boundary otic vesicle pharyngeal arch mandibular arch hyoid arch branchial arch rbm28 X. tropicalis Sometime during NF stage 35 and 36 to NF stage 40 eye midbrain-hindbrain boundary brain otic vesicle pharynx sbds X. tropicalis Sometime during NF stage 35 and 36 to NF stage 40 head utp4 cirh1a, cirhin, tex292 X. tropicalis Sometime during NF stage 35 and 36 to NF stage 40 liver head Image source: Published Larger Image Printer Friendly View

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