Figure 5. Effects of Eya1 knockdown on target genes. Tail bud (AâG) and neural plate (HâI) stage embryos after unilateral injection of Eya1-MO1+2. In each case, lacZ was co-injected as a lineage tracer and panels A1âG1 show the control (un-injected) side and A2âG2 show the injected side (lacZ staining out of frame in most specimens). The injected side is positioned to the right in HâJ, as marked by blue lacZ staining. Arrows and arrowheads mark reductions in marker gene expression in placodal and non-placodal derivatives, respectively.
Image published in: Riddiford N and Schlosser G (2016)
© 2016, Riddiford et al. Creative Commons Attribution license
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| neurog1.L | neurod3, neurogenin, neurogenin 1, neurogenin-1, neurogenin1, ngn, ngn1 | X. laevis | Throughout NF stage 18 | chordal neural plate chordal neural plate border Rohon-Beard neuron neurogenic placode |
| sox2.S | anop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2 | X. laevis | Throughout NF stage 18 | neural plate pre-chordal neural plate chordal neural plate neural groove eye primordium optic vesicle |
| sox3.L | Sry, Xlsox3, xSox3, Xtsox3 | X. laevis | Throughout NF stage 18 | neural plate pre-chordal neural plate chordal neural plate optic vesicle eye primordium |
| atoh1.L | ath1, bhlha14, hath1, math-1, math1, xath-1 | X. laevis | Throughout NF stage 28 | hindbrain neurogenic placode otic vesicle |
| gfi1.L | gfi1a | X. laevis | Throughout NF stage 28 | neurogenic placode trigeminal placode lateral line ganglion ventral blood island |
| hes5.4.L | hes8 | X. laevis | Throughout NF stage 28 | trigeminal placode trigeminal ganglion trigeminal nerve retina olfactory placode eye |
| hes5.6.L | X. laevis | Throughout NF stage 28 | retina eye hindbrain midbrain forebrain telencephalon trigeminal placode trigeminal ganglion trigeminal nerve | |
| pou4f4.L | Brn3d, pou4f1.2 | X. laevis | Throughout NF stage 28 | trigeminal placode trigeminal ganglion trigeminal nerve otic vesicle neurogenic placode |
| tlx1.L | hox11, hox11-a, LOC108697427, Xhox11, XHox11L2 | X. laevis | Throughout NF stage 28 | trigeminal placode trigeminal ganglion otic vesicle neurogenic placode heart primary heart field secondary heart field |
| isl2.L | islet-2, islet2b, LOC108711275 | X. laevis | Throughout NF stage 28 | trigeminal placode trigeminal ganglion trigeminal nerve otic vesicle neurogenic placode spinal cord |
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