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Fig. 4. Impact of ANK2-C terminus and its mutant E1813K on functional KCNH2 expression in Xenopus oocytes. A, Mean current traces obtained by depolarization to 45 mV with tail currents at −100 mV with the standard error value indicated by light shading (n = 20 each) for channels formed by KCNH2 and KCNH2-H562R (left), as well as coexpression of the C-terminal domain of ANK2 (“ANK”, middle) or its mutant E1318K (“ANK-E1318K”, right). B, Normalized peak tail currents from experiments as in A for four independent batches of oocytes (n = 20 each). Data are means ± s.e.m. The blue bars correspond to the experiment in A, the open bars are means of all experiments. n.s. not significant; ***P < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Image published in: Gessner G et al. (2019)

Copyright © 2019. Image reproduced with permission of the Publisher, Elsevier B. V.

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