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Figure 7. . Effect of external Ca2+ on the activation of homomeric ASIC channels. Whole cell currents from oocytes injected with ASIC1α (A), ASIC2 (B), or ASIC3 (C) were activated by pHo 5.0 in the presence of absence of 1 mM Ca2+ in the bath solution. Only ASIC3 requires external Ca2+ for activation by protons with an apparent CE50 of 0.28 mM (inset in C). Recordings were performed with TEVC, 150 mM Na+ in the bath and −60 mV membrane potential. Time and amplitude are indicated by the scale bars.

Image published in: Zhang P and Canessa CM (2002)

Copyright © 2002, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license

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