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Fig. 1. Comparison of ionotropic glutamate receptor sequences and NMDA receptor antagonists used in this study. A, Sequence alignment of the M2-M3 regions of GluA1, GluA2, GluN1-1a, GluN2A, GluN3A and GluN3B subunits. Highlighted with ● is the Q/R/N site and ○ is the N + 1 site. Other amino acids of interest are indicated by ▲ and numbered by their relationship to the N site. Highlighted in black are conserved amino acids. B, 2-D structures of memantine, (+)-MK-801, PhTX-343 and methoctramine.

Image published in: McClymont DW et al. (2012)

© 2012 Elsevier B. Creative Commons Attribution license

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