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Figure 2. MCT1 expressed in Xenopus oocytes is inhibited by AR-C155858 in a time- and concentration-dependent mannerXenopus oocytes were injected with the appropriate cRNA and after 72 h expression were pre-incubated in pH 6 oocyte transport buffer in the presence or absence of 0.1 μM or 1 μM AR-C155858 for the times shown. The uptake of 0.5 mM L-[14C]lactate uptake was then determined after 2.5 min over which period it was found to be linear with time. Data are shown as means±S.E.M of ten separate oocytes. The inset shows the uptake of 20 mM L-lactate measured at pH 6.0 using the pH-sensitive dye BCECF. Data are presented for the same oocyte in the absence of inhibitor and then after 20 min superfusion with 0.1 μM and 1 μM AR-C155858.

Image published in: Ovens MJ et al. (2010)

© 2010 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons. Creative Commons Attribution-NonCommercial license

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