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Figure 7. . Analysis of α-helical periodicity in the S5-P linker based on perturbations of activation gating induced by cysteine mutations (data from DTT-treated channels). The methods of calculating the Fourier transform power spectrum (P(ω) vs. ω) and α-periodicity index (α-PI) are described in materials and methods. (A) Fourier transform power spectrum of |ΔΔGo| values for the segment of 583–597 (value for the nonfunctional K595C is taken from ). (B) Windowed α-periodicity index analysis of S5-P linker of HERG. The α-PI values are calculated with a 15-residue sliding window and plotted against WT residues with selected position numbers along the abscissa (putative α-helix “583–597” is boxed).

Image published in: Liu J et al. (2002)

Copyright © 2002, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license

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