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Fig. 4. CB1 antagonist AM251 alters odor-evoked electrical activity in individual ORNs. (A1) AAMIX-induced action potential-associated currents of an individual ORN. [Scale bars: 2 s and 20 pA (A1–A5).] The corresponding poststimulus time histogram is shown in B1. The superimposed red histogram comes from a successive AAMIX application (interstimulus interval 3 min; current trace not shown) and shows the high reproducibility of the odorant response. (A2–A4 and B2–B4) The modulatory effect of AM251 on the action potential-associated currents depends on the wash-in time of the antagonist. (A5 and B5) Recovery after 20-min drug washout. The time window of the original response is indicated by the gray-shaded area. (A6 and B6) Odor concentration time course. Shown is simulation of the odor dynamics during a single odorant application (see Materials and Methods). (C1–C5) Zoom of individual spike-associated currents, one from each current trace A1–A5 (trace duration 25 ms). (Scale bar: 40 pA.) Image published in: Czesnik D et al. (2007) Copyright © 2007. Image reproduced with permission of the Publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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