Xenbase Image ID: 125938

Figure 3. Global expression changes upon HoxA3 induction(A) Venn diagram of regulated genes in endothelial (F/V) and hematopoietic (K/41) progenitor cells. Arrow up upregulated genes, arrow down downregulated genes. (B) Clustering of genes upregulated in the c-Kit CD41 double-positive cells upon HoxA3 induction, during EB differentiation in the hematopoietic c-Kit CD41 double positive cells, based on their expression levels in the Flk-1 VE-cadherin double positive cells (F/V) and in the c-Kit CD41 double positive cells (K/41) of uninduced EBs. (C) Clustering of genes downregulated genes in the Flk-1 VE-cadherin double-positive population upon 6-hour HoxA3 induction, in day 6 EB cells, based on their baseline (control) levels in the Flk-1 VE-cadherin double-positive population (F/V). (D) Real time RTPCR measurements of gene expression changes following HoxA3 induction in sorted endothelial (F/V black bars) or hematopoietic (K/41 grey bars) progenitors. n=5 independent experiments. Image published in: Iacovino M et al. (2011) Image downloaded from an Open Access article in PubMed Central. Image reproduced on Xenbase with permission of the publisher and the copyright holder. Larger Image Printer Friendly View

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