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Figure 4. Adding negative charge to the transmembrane cavity increases affinity for Mg2+ but not for Na+ or TEA+. Block was analyzed in WT and N152D channels according to Eq. 3 at 11 mM of extracellular K+ for (A) 0.2 mM Mg2+, (B) 40 mM Na+, and (C) 3 mM TEA+. Typical current traces at two voltages with and without blockers are shown at the top of each panel. A transition in the presence of TEA+ is magnified in the inset. Values of Ki(0) decreased from 0.81 to 0.11 mM (Mg2+), and increased from 117 to 138 mM (Na+) and 1.8 to 2.2 mM (TEA+). No significant changes in zδ were observed.

Image published in: Yang L et al. (2012)

© 2012 Yang et al. Creative Commons Attribution-NonCommercial-ShareAlike license

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