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Figure 4—figure supplement 2. The Asp388 neutralization mutation of MmOTOP1 also reduces the channel’s rate of desensitization.(a) Sample traces of whole-cell currents of the wild type MmOTOP1 and Asp388Asn mutant (left), and the overlay of traces with the mutant trace scaled to that of the wild-type. (b) Sample traces of patch clamp recordings in the outside-out configuration of the wild type MmOTOP1 and Asp388Asn mutant (left), and the overlay of traces with the mutant trace scaled to that of the wild-type. All recordings were performed at −100 mV with pHi = 7.4. The currents were elicited by changing pHo from 7.4 to 5.0. Image published in: Chen Q et al. (2019) © 2019, Chen et al. Creative Commons Attribution license Larger Image Printer Friendly View

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