Xenbase Image ID: 117829

Figure 8. A model for the assembly of immature HIV capsids. This model is based on the simplest interpretation of the data presented. Newly synthesized Gag proteins are myristoylated cotranslationally. Nascent Gag polypeptides appear to chase into completed immature capsids by way of a series of Gag-containing complexes (complexes A, B, C, and D). Evidence presented in the text suggests that complexes A, B, and C may constitute assembly intermediates. It is less clear whether complex D constitutes an assembly intermediate or a side reaction. Both ATP and a subcellular fraction of eukaryotic cell extract are required for assembly to take place, while detergent and apyrase are proposed to disrupt assembly at the indicated position. The points along the pathway at which various mutants of Gag are arrested are indicated below the model. Image published in: Lingappa JR et al. (1997) Image reproduced on Xenbase with permission of the publisher and the copyright holder. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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