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Figure 9. Summary, crosstalk, and working model for observed discrete localization of rho GTPase activity zones during wound healing. (A) Schematic shows observed concentric subcellular compartmentalization of RhoA and Cdc42 activity zones at wound border, summary of crosstalk, and their respective effects on actin dynamics. (B) Diagram shows working model for maintenance of wound-induced response. Upon wounding, a cytoplasmic activity module (inside box) is established in which activation of localized RhoA and Cdc42 leads to directed cortical contraction and flow, which cause accumulation of both actin and microtubules, which, in turn, further promotes zones of activity. Image published in: Benink HA and Bement WM (2005) Copyright © 2005, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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