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Figure 5. The rate of gating charge return in W434F channels is affected by ionic conditions. Double-pulse protocols with variable interpulse intervals were used to assess the kinetics of gating charge return by observing the recovery of IgON in the second pulse. (A) In the presence of internal K+, only gating currents are observed and recovery of peak IgON in the second pulse follows the falling phase kinetics of IgOFF. (B) In a K+-free internal Na+ solution, IgON shows an initial delay in recovery that coincides with the rising phase of the ionic tail current. This is followed by a recovery phase in which IgON peaks increase with a time course that parallels the deactivation phase of the ionic tail current. For dashed curves see text. Image published in: Starkus JG et al. (1998) Image reproduced on Xenbase with permission of the publisher and the copyright holder. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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