XB-IMG-121139
Xenbase Image ID: 121139
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Figure 1. Schematic diagram of wild-type mSlo1 channels, wild-type mSlo3 channels, mSlo1 tail channels and mSlo3 tail channels. The position of the calcium bowl in the mSlo1 tail is indicated. The proposed membrane topology of the four studied channels is shown in the top diagram and the components of the various channels is indicated in the schematic diagrams below. The mSlo1 tail channels are expressed from mSlo1 core domains (S0âS8) and mSlo1 tail domains (S9âS10). The mSlo3 tail channels are expressed from mSlo1core domains and mSlo3 tail domains. The mSlo3 core domain (residues 35â641) shares 56% identity with the mSlo1 core domain. The mSlo3 tail domain (residues 686â1136) shares 39% identity with the mSlo1 tail domain (Schreiber et al. 1998). A linker region with little identity is found between S8 and S9. Compared with the mSlo1 tail, the mSlo3 tail has six fewer negatively charged residues in the calcium bowl region. (Adapted from Schreiber et al. 1999.) Image published in: Moss BL and Magleby KL (2001) © 2001 The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View |