Xenbase Image ID: 122449

Figure 1. . Schematic depiction of the Na channel α subunit. It consists of four domains, each of which has six transmembrane segments. The S4 segments represent at least part of the voltage sensor. The segments between S5 and S6 (P-segments) line the outer pore. The outer ring of negative charge (E403, E758, D1241, and D1532) is illustrated in filled circles. The open circles represent the putative selectivity filter residues (D400, E755, K1237, and A1529). The domain III-IV linker underlies fast inactivation. The 13 double cysteine mutants studied are shown below the schematic. E403C, E758C, and D1241C (enclosed in the boxes) were paired with other cysteine mutants in different domains of the outer pore. Image published in: Xiong W et al. (2003) Copyright © 2003, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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