XB-IMG-126116
Xenbase Image ID: 126116
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FIG. 4. MgADP and MgATP activation of SUR1-E1506 mutations on a Kir6.2-G334D background. MgADP and MgATP activation of KATP channels composed of Kir6.2-G334D and WT or mutant SUR1, as indicated. The number of patches is indicated below the bars. A: The maximal KATP current after patch excision is expressed relative to that in the cell-attached patch. KATP current (I) in the presence of 100 μmol/L MgADP (B) or 100 μmol/L MgATP (C) is expressed relative to the current in the absence of nucleotides (IC). *P ⤠0.05, **P ⤠0.01, ***P ⤠0.001 against wild type (Student t test). Statistical significance between mutant E1506 channels is reported in Supplementary Table 1. The error bars show the SEM. Image published in: Männikkö R et al. (2011) © 2011 by the American Diabetes Association. Creative Commons Attribution-NonCommercial-NoDerivatives license Larger Image Printer Friendly View |