XB-IMG-127025
Xenbase Image ID: 127025
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Figure 6. Matrix metalloproteinase (MMP) expression during re-epithelialization and new tissue formation.Expression values (y-axis) reflect absolute expression values from Affymetrix axolotl genechips (see Table S1 for exact values). Error bars represent standard error. Blue lines represent paedomorphs and red lines represent metamorphs. Expression kinetics for selected MMPs generally followed two patterns; (1) a strong upregulation at D1 followed by an equally strong decrease at D3 and a continued decrease or leveling off at D7 [MMP3/10a, MMP9] and (2) a strong upregulation at D1 which remained high at D3 and then downregulated at D7 [MMP3/10b, MMP19]. For MMP28 the kinetics followed pattern 1 for paedomorphs and pattern 2 for metamorphs suggesting that MMP28 expression was highly connected to re-epithelialization. The expression profile for MMP2 was unique in that is was downregulated following injury and was upregulated after re-epithelialization was complete. Image published in: Seifert AW et al. (2012) Seifert et al. Creative Commons Attribution license Larger Image Printer Friendly View |