Xenbase Image ID: 122411

Figure 1. . Effect of intracellular CPA on macroscopic currents of the CLC-0 mutant C212S. (A) Currents recorded from an inside out patch in control conditions with a pulse protocol in which, after a 400-ms pulse to −140 mV, to maximally deactivate the channels, the voltage was varied between Vp = −140 and +60 mV, followed by a constant tail pulse to +60 mV. Only the traces for Vp = +60, +20, and −60 are shown. The inset shows a schematic representation of the pulse protocol. (B) Currents recorded from the same patch in the presence of 5 mM CPA in the intracellular solution. The inset shows the chemical structure of CPA. Scale bars in A apply also to B. Image published in: Accardi A and Pusch M (2003) Copyright © 2003, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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