XB-IMG-123923
Xenbase Image ID: 123923
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Fig. 4. Effects of MTS reagents on ATP concentration responses at P2X1 receptor mutants. Concentration response curves to ATP were determined under control conditions or following incubation with MTSEA (1 mM for 1 h followed by washout) or MTSES (1 mM for 3 h followed by washout). (a) At T186C the EC50 was significantly increased by both MTSEA and MTSES with no effect on the peak response. (b) At K190C MTSEA significantly increased whilst MTSES significantly decreased ATP potency. For MTSES peak current responses were also reduced. (c) MTSEA and MTSES treatment reduced responses at the F195C mutant receptor by > 90% even for a maximal concentration of ATP (1 mM). Image published in: Roberts JA et al. (2009) Journal compilation © 2009 International Society for Neurochemistry. Creative Commons Attribution license Larger Image Printer Friendly View |