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Figure 7. Single channel activity for different variants of CaV1.2 in the presence of CaVβ2a. (A) Representative traces from four patches containing CaV1.2 WT, CaV1.2 E462R, CaV1.2 K465N, and CaV1.2 W470S coexpressed with CaVβ2a during 200-ms depolarizations to 0 mV repeated at 1 Hz from a holding potential of −70 mV. Calibration bar corresponds to 50 ms and 2 pA. (B) Diary plots showing the calculated Po versus trace number for CaV1.2 variant shown in A. (C) Po histograms in logarithmically binned histograms for CaV1.2 variants shown in A. Note that CaV1.2 W470S yields a mono-modal Po distribution.

Image published in: Gonzalez-Gutierrez G et al. (2008)

© 2008 Gonzales-Gutierrez et al. Creative Commons Attribution-NonCommercial-ShareAlike license

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