Xenbase Image ID: 116285

Figure 3. N604S forms functional channels, with properties like that of wild type. (A) Current family activated by a saturating capsaicin concentration (4 μM) in an outside-out patch obtained from stepping the voltage from a holding potential of 0 mV to between -100 and +100 mV. (B) Current-voltage relation for currents activated by 4 μM capsaicin for N604S (blue) and wild-type VR1 channels (green). Data were normalized to the value of the current at-100 mV. (C) Current family activated by a sub-saturating capsaicin concentration (0.5 μM). (D) Current-voltage relation for currents activated by 0.5 μM capsaicin for N604S (red) and wild-type VR1 (green) channels. Data were normalized to the value of the current at -100 mV. (E) Dose-response relations for activation by capsaicin plotted on a double-log scale. The smooth curves are fits with the Hill equation with K½ = 905 nM, Imax = 114 pA, and n = 1.8. Filled circles represent actual data values, plotted on a double-log axis. All data in this figure is from the same patch. Image published in: Rosenbaum T et al. (2002) Image downloaded from an Open Access article in PubMed Central. Copyright © 2002 Rosenbaum et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Larger Image Printer Friendly View

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