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Figure 1. (A) Effects of various divalent metal ions on the steady state current of the ClC-0 Cl− channel. The membrane potential of the oocyte was clamped at −30 or −40 mV. Each circle represents the current amplitude monitored by a 100-ms voltage pulse to +30 or +40 mV given every 5 or 6 s. Dotted lines show zero-current level. Solutions containing desired concentrations of various heavy metal ions were perfused in (downward arrows) and out (upward arrows), as indicated. (B) Concentration-dependent inhibition of the steady state current by Zn2+. Holding potential was at −30 mV. Continuous recording at 27.4°C for more than 50 min.

Image published in: Chen TY (1998)

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