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Figure 1. Simulation of symmetric and asymmetric antiporter kinetics in an artificial cell containing LAT2 only. The concentration of cytosolic and extracellular amino acids was set at 1 mM. (a) Intracellular concentrations of all substrate amino acids when LAT2 intracellular KM values were scaled to be 180-fold higher than extracellular KM values. (b) Intracellular concentrations of all substrate amino acids when the intracellular KM value of Gly was scaled to be 0.6-fold higher than the extracellular KM value (all other KM values as in (a)). Gly (beige) is leaving the cell in exchange for all other substrates of the transporter. Image published in: Gauthier-Coles G et al. (2023) Copyright © 2023. OA ARTICLE, images redisplayed under a Creative Commons license. Larger Image Printer Friendly View

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