XB-IMG-126148
Xenbase Image ID: 126148
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Figure 3. Effect of FGF signaling, cell movement and cell proliferation on axis elongationa–p, Control (lavender) and treated (orange) conditions. a, e, j, l, n, p, Quantification of elongation. c, g, Convergence analysis. b, f, i, k, m, o, Mean cellular motility analysed along the AP axis. d, h, Analysis of PSM cellular density along the AP axis. The solid line represents a curve fitted to the mean value and the standard deviation is represented by the corresponding light-colored bars (n=4 or 5 for each condition). a–d, Inducible FGFR1dn electroporation. e–h, FGF8 electroporation. i,j, Y27632 treatment. k,l, Blebbistatin treatment. m,n, Aphidicolin treatment. o,p, Mitomycin treatment. b,f mean of two [for FGFR1dn] or three embryos [for FGF8]; errors bars represent the standard deviation). q, Model of the control of elongation by a gradient of random cellular motion in the PSM. Dorsal view of a schematic representation of the left PSM at two consecutive stages of embryo elongation. While new cells are entering the PSM, the gradient of random motility (lavender gradient; black arrow clusters) opposed to the gradient of cellular density (orange gradient) creates a directional bias in elongation (blue arrows) toward the posterior part of the tissue. This posterior expansion induces the convergence of the PSM tissue (red arrow). Image published in: Bénazéraf B et al. (2010) Image downloaded from an Open Access article in PubMed Central. Image reproduced on Xenbase with permission of the publisher and the copyright holder. Larger Image Printer Friendly View |