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Figure 3. HP effects on GluN2C and GluN2D NMDAR subtypes. (A) HP differentially modulates GluN2C subtype currents. Top: HP moderately decreases GluN1-1a + GluN2C current. Bottom: HP greatly decreases GluN1-1b + GluN2C current. Note only partial recovery of the response. (B) HP selectively modulates GluN2D subtype currents. Top: GluN1-1a + GluN2D seem to be “pressure-resistant.” Bottom: HP decreases GluN1-1b + GluN2D current. Note complete recovery after a full decompression. For all traces: the applied agonist concentrations were 100 μM (glutamate) and 10 μM (glycine) with no [Mg2+]o added. The 20 s agonist application time is indicated by horizontal bars.

Image published in: Mor A et al. (2012)

Copyright © 2012 Mor, Kuttner, Levy, Mor, Hollmann and Grossman. Creative Commons Attribution license

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