XB-IMG-127577
Xenbase Image ID: 127577
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Figure 1. Confirmation of NMDAR expression in Xenopus laevis oocytes. Top: increasing extracellular [Mg2+] blocked NMDAR ionic current in a concentration-dependent manner (expected for all wild-type NMDARs). Bottom: activation of NMDAR requires simultaneous application of the co-agonists glutamate (100 μM) and glycine (10 μM), with no [Mg2+]o added. Agonist application time was 20 s (horizontal bars). GluN1-1b + GluN2B currents are shown as an example. The same measurements were performed with the other subunit combinations, confirming NMDAR currents in each case. Image published in: Mor A et al. (2012) Copyright © 2012 Mor, Kuttner, Levy, Mor, Hollmann and Grossman. Creative Commons Attribution license Larger Image Printer Friendly View |