Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-IMG-128914

Xenbase Image ID: 128914


Figure 3. Sox4 depletion interferes with retinal lamination.Unilateral injection of 40 ng Sox4 or 40 ng Sox11 MO had no effect on the primary formation of most retinal cell types as shown by the expression of specific marker genes in mild eye phenotypes at stage 41. Only ganglion cells disappeared upon depletion of Sox4 or Sox11 in the severe eye phenotype. Many retinal cells were displaced (red arrowheads). Especially photoreceptor cells are displaced into inner layers of the retina (red arrowheads). In addition, the RPE is affected (black arrowheads). The uninjected (uninj.) sides revealed normal retinal lamination. For each marker gene, several embryos of different independent experiments were analyzed and showed a similar phenotype. Scale bar indicates 100 µm.

Image published in: Cizelsky W et al. (2013)

Image reproduced on Xenbase with permission of the publisher and the copyright holder. Creative Commons Attribution license

GeneSynonymsSpeciesStage(s)Tissue
arr3.LX. laevisThroughout NF stage 41lens
photoreceptor layer
rho.Lopn2, rh1, rhodopsin, rp4, xrhoX. laevisThroughout NF stage 41photoreceptor layer
prox1.Lprospero, prospero homeobox protein 1, prospero-related homeobox 1, Prox 1, xprox1X. laevisThroughout NF stage 41horizontal cell
retinal inner nuclear layer
lens
vsx1.Lktcn, ppcd, ppd, rinx, Xvsx1X. laevisThroughout NF stage 41retinal inner nuclear layer
bipolar neuron
lens
pax6.Lan2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6X. laevisThroughout NF stage 41amacrine cell
retinal ganglion cell layer
retinal ganglion cell
pou4f1.LBrn3.0, brn3a, LOC108709765, oct-t1, POU class IV homeobox 1, rdc-1X. laevisThroughout NF stage 41retinal ganglion cell layer
retinal ganglion cell
lens

Image source: Published

Larger Image
Printer Friendly View

Return to previous page