Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-IMG-84480

Xenbase Image ID: 84480


Fig. 2. RA signaling inhibits lens regeneration, and RA signaling antagonism does not inhibit lens regeneration. (A) Liarozole and TTNPB are potent inhibitors of cornea-lens regeneration. A high concentration of RA very strongly inhibits lens regeneration. ⁎ indicates p<0.0001, using two-tailed Fischer's exact test. (B) A drug-treatment validation assay using qPCR shows that all of the drugs strongly activate RA signaling, as seen by a profound upregulation of cyp26a1, a marker of active RA signaling, in the cornea. ⁎ indicates p<0.01, using unpaired t test. (C) Citral and LE-135, inhibitors of RA signaling, fail to inhibit cornea-lens regeneration. (D) A drug-treatment validation assay using qPCR shows that LE-135 attenuates expression of cyp26a1 in the cornea. ⁎ indicates p<0.0001, using unpaired t test. All error bars indicate standard error.

Image published in: Thomas AG and Henry JJ (2014)

Copyright © 2014. Image reproduced with permission of the Publisher, Elsevier B. V.

Larger Image
Printer Friendly View

Return to previous page