XB-IMG-127112
Xenbase Image ID: 127112
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Figure 3. Fit a 13-parameter Nav-like C5-O-I-CI5 model to the target current traces.(A) A 13-parameter Markov model consisting of five closed states (C0, C1, C2, C3 and C4), an open state (O), an inactivation state (C10) and five closed-inactivation states (C5, C6, C7, C8 and C9). Each of parameters to be fitted is similar to that we described in Figure 1(A). (BâC) See the description in Figure 1BâC. (D) In this model, the target parameters mâ=â288.655598 msâ1, nâ=â12 mV, pâ=â22.144593 msâ1, qâ=â48 mV, râ=â7.5 msâ1, sâ=â2 msâ1, gâ=â0.001, dâ=â0.5 msâ1, câ=â4.436203, uâ=â0.9 msâ1, wâ=â0.006 msâ1 and jâ=â4 msâ1; the reversal potential of channels Vrâ=â+55 mV; the single-channel conductance Gâ=â250 pS and the channel count NCâ=â1. A dependent parameter iâ=â15 msâ1. The empty circles denote target currents and the solid lines represent fitted currents. The voltage protocols are placed below each of current traces. Image published in: Wang W et al. (2012) Wang et al. Creative Commons Attribution license Larger Image Printer Friendly View |