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XB-IMG-125304

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Figure 2. Phosphorylation dependence is little affected by site-1 and site-2 mutations. (A–D) Inward chloride currents recorded in patches excised from resting oocytes expressing WT (A), F1296S (B), N1303Q (C), and F1296S/N1303Q (D) CFTR. In each case, the application of 2 mM ATP (bars) elicits only small currents relative to those activated by subsequent exposure to 300 nM PKA plus 2 mM ATP (bars). Note the rapid partial deactivation after the removal of PKA in A–D and the persistent channel activity after the removal of ATP in D (magnified in inset). Membrane potential was −80 mV in A–C, but −20 mV in D.

Image published in: Szollosi A et al. (2010)

© 2010 Szollosi et al. Creative Commons Attribution-NonCommercial-ShareAlike license

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