Xenbase Image ID: 129109

Figure 5. Increased re-epithelialisation and proliferation in human skin following 17β-estradiol treatment.(A) Representative H&E stained sections of human skin punch-wounds following 6 days culture with either vehicle control, 100 nM or 1 µM 17β-estradiol (Est). New epithelial tongue indicated by red lines, scale bar represents 50 µm. (B) Representative images of Ki-67-TUNEL double-stained sections of human skin punch wounds following 6 days culture with either vehicle control, 100 nM or 1 µM 17β-estradiol. The white-hatched line demarcates new epithelial tongue. (C) The graph displays length measurements of the new epithelial tongue (as demarcated by the red lines in A) as analysed from H&E stained human skin sections following treatment with vehicle control, 100 nM and 1 µM 17β-estradiol. (D) Percentage of proliferative (Ki67-positive) cells in the new epithelial tongue of vehicle control, 100 nM and 1 µM 17β-estradiol-treated human skin wounds. (E) Percentage of apoptotic (TUNEL-positive) cells in the new epithelial tongue of vehicle control, 100 nM and 1 µM 17β estradiol-treated human skin wounds. Data are mean ± SEM of 4 female donors. Significance relative to control data denoted by *P<0.05, **P<0.01, ***P<0.001. Image published in: Meier NT et al. (2013) Image reproduced on Xenbase with permission of the publisher and the copyright holder. Creative Commons Attribution license Larger Image Printer Friendly View

Return to previous page