Xenbase Image ID: 123337

Figure 1. OGT sequence conservation. Alignment of OGT sequences from Xanthomonas campestris pv. campestris (XcOGT), Caenorhabditis elegans (CeOGT), Xenopus laevis (XlOGT) and human (hOGT, isoform 1). N termini of hOGT constructs are indicated by arrows. Secondary structure elements (cylinders/arrows) are shown, a brown bar marks the active site lid. coloured bars indicate the TPRs (yellow=A helix; orange=B helix), the TLRs (green), the connecting loop (light green), the N-terminal GT-B subdomain (cyan), the intersubdomain linker (blue) and the C-terminal GT-B subdomain (magenta). Blue triangles give the location of the previously described (triangle up) and proposed additional (triangle down) PIP3-interacting residues, orange and red circles locate point mutations described previously and in the present work, respectively. Labels represent hOGT/XcOGT residues. Image published in: Clarke AJ et al. (2008) Copyright © 2008, European Molecular Biology Organization. Creative Commons Attribution-NonCommercial-NoDerivatives license Larger Image Printer Friendly View

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