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FIGURE 5. Effect of cysteine scanning mutagenesis of the DIV-S6 segment on IUS. Shown is the result of double exponential fits (Equation 1) to the time course of recovery from a prolonged depolarization as shown in Fig. 1A. Because of the low amplitude of recovery from IUS in these mutants, the parameter τ2 was fixed at 120 s during the fitting procedure. The asterisks indicate significant differences from wild type (**, p < 0.01; ***, p < 0.001; n = 5–7). With the exception of I1575C, all mutants significantly enhanced recovery from IUS, indicating a role of the DIV-S6 segment in the generation of the IUS state. Mutants I1576C and N1584C did not express sufficient current to be studied. Image published in: Zarrabi T et al. (2010) © 2010 by The American Society for Biochemistry and Molecular Biology, Inc. Creative Commons Attribution-NonCommercial license Larger Image Printer Friendly View

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