Xenbase Image ID: 129739

Figure 6. Cys-13 on DPP6a is the target of both tBHP- and diamide-induced oxidation.A. Kv4.2+KChIP3a+DPP6a/C13S currents in response to 500-ms-long depolarization at +60 mV before and after 1 mM tBHP treatment. Multiple traces are overlapped to show that the current is no longer sensitive to tBHP. B. Response of 500-ms-long Kv4.2+KChIP3a+DPP6a/C13S current at +60 mV to 0.4 mM diamide. Again, overlapped multiple traces show that the mutation C13S renders DPP6a insensitive to diamide. C. Quantitative measurements of change in peak current before and after oxidant treatment. With tBHP, n = 3; with diamide, n = 7. Image published in: Jerng HH and Pfaffinger PJ (2014) Image reproduced on Xenbase with permission of the publisher and the copyright holder. Creative Commons Attribution license Larger Image Printer Friendly View

Return to previous page