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Xenbase Image ID: 121158

Figure 8. Model illustrating the mechanism by which mutations of αS589 may enlarge the channel pore at the selectivity filter. Residue αS589 and analogues in the β and γ subunit arranged around the channel pore are shown in a cross-section of the pore seen from the top for wt ENaC (left) and the mutant αS589N (right). Each residue is represented by its backbone part in gray, with the carbonyl oxygen shown as a hatched circle pointing toward the pore lumen and the side chain identified by the black edge. The side chains are located at the interface between the subunits. Increasing the size of the side chain of the two αS589 residues adds extra volume at the subunit–subunit interface and makes the pore wider.

Image published in: Kellenberger S et al. (2001)

© 2001 The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license

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