Xenbase Image ID: 122364

Figure 1. . Low internal K+ reveals two components of external TEA block. Fraction of Shaker K+ channel current blocked by external TEA in 50 mM (A) and 5 mM (B) internal K+ at −10 mV (top) and +70 mV (bottom). Data points are the mean values from 3 to 6 measurements with standard error limits for those whose errors are larger than the symbol size. Insets show raw currents in the absence (Control) and presence of 50 mM external TEA. Calibrations: (A) −10 mV, 50 pA/10 ms; +70 mV, 0.2 nA/10 ms; (B) −10 mV, 50 pA/10 ms; +70 mV, 0.1 nA/10 ms. Dashed lines are fits of Eq. 1 to the data with Kapp values of (A) −10 mV, 20 mM; +70 mV, 43 mM; (B) −10 mV, 32 mM; +70 mV, 89 mM. Solid lines are fits of Eq. 2 to the data with the A, Kapplow, and Kapphigh parameter values shown in Fig. 2. Image published in: Thompson J and Begenisich T (2005) Copyright © 2005, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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