XB-IMG-129125
Xenbase Image ID: 129125
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Figure 3. The Uhrf1-dependent replication defect does not reflect a requirement for Dnmt1 loading. (A) Mock-, Dnmt1- and Uhrf1-depleted extracts supplemented with sperm chromatin were incubated at 21°C, and DNA replication was measured by continuous incorporation of α-32PdCTP. Data from three independent experiments are presented. (B) Western blot indicating levels of Uhrf1 and Dnmt1 in depleted and mock-depleted extracts relative to Orc1 loading control. Image published in: Taylor EM et al. (2013) © The Author(s) 2013. Creative Commons Attribution license Larger Image Printer Friendly View |