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Figure 4. Lack of ρ1 increased duration of LORR by ethanol and ketamine but not pentobarbital or flurazepam.A, B, C, D – Males. E, F, G, H – Females. A, E – Ethanol (n = 8–10 per genotype for both sexes; t(16) = 3.3 for males and females, **p<0.01 vs. wild type of corresponding genotype). B, F – Pentobarbital (n = 12–15 per genotype for both sexes). C, G – Ketamine (n = 10–14 per genotype for both sexes; t(25) = 2.9 for males and t(22) = 6.3 for females, **p<0.01, ***p<0.001 vs. wild type of corresponding genotype). D, H – Flurazepam (n = 7–10 per genotype for both sexes). Values represent mean ± S.E.M. Data were analyzed by Student's t-test. ρ1 (−/−) = ρ1 null mice; (+/+) = wild type mice; EtOH = ethanol; LORR = loss of righting reflex. Image published in: Blednov YA et al. (2014) Image reproduced on Xenbase with permission of the publisher and the copyright holder. Creative Commons Attribution license Larger Image Printer Friendly View

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