XB-IMG-128410
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Figure 5. Reconstruction of SI based on voltage-sensor models. Models of the voltage sensors from our companion paper (Fig. 8 in Silva and Goldstein, 2013) and Fig. 4 are linked in various ways in an effort to recapitulate SI kinetics. (A) WT ionic SI from our companion paper (Fig. 2 in Silva and Goldstein, 2013). Axes adjusted for comparison to other panels. (B) Simulated ionic SI requiring all four sensors makes a slow transition. (C) Simulated ionic SI requiring any one voltage sensor makes a slow transition. (D) Simulated ionic SI requiring DI, DII, or DIII, but not DIV. (E) Simulated ionic SI requiring the L689I/TTX-sensitive component of DI and DII coupled with the sensor transition of DIII. (F) Simulated ionic SI requiring the L689I/TTX-sensitive component of DI and DII with the slow I1→I2 and I2→I3 movements of DIII. (G) Experiment from our companion paper (Fig. 6 in Silva and Goldstein, 2013) showing ionic current recovery from SI for comparison to the model. (H) Simulated recovery from SI using the same mathematical model applied to simulate SI onset in F. Image published in: Silva JR and Goldstein SA (2013) © 2013 Silva and Goldstein. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View |