XB-IMG-124409
Xenbase Image ID: 124409
|
Figure 1. acr-2 locus.(A) Genetic position of acr-2 on the left arm of the X chromosome. (B) Representative cosmids and subclones used in germline transformation rescue of acr-2(n2420gf). Rescue of spontaneous convulsion is indicated by a plus sign (+); and no rescue by a minus sign (−). Canonical cosmids F38B6 and K11G12 are shown in parentheses. (C) ACR-2 is a member of the UNC-29 class non–α-subunits of the acetylcholine receptor family [14]. (D) The n2420 mutation causes a valine-to-methionine change in the 13′ position of the pore-forming second transmembrane domain (TM2, residues are colored in teal). The amino acid at the 13′ position is oriented toward the pore; orange mark residues lining the pore [20]. Image published in: Jospin M et al. (2009) Jospin et al. Creative Commons Attribution license Larger Image Printer Friendly View |